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Ferrostatin-1（鐵抑素-1）

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Ferrostatin-1 是一種有效的、選擇性的 ferroptosis 抑制劑，抑制 Erastin 誘導(dǎo)的 HT-1080 細(xì)胞鐵死亡 (EC50=60 nM)。Ferrostatin-1 是一種人工合成的抗氧化劑，通過還原機(jī)制來防止膜脂的損傷，從而抑制細(xì)胞死亡。具有抗真菌活性。
貨號： HY-100579
參數(shù)品牌：MCE
產(chǎn)品參數(shù)
品牌：MCE
型號： HY-100579
起訂量：1
規(guī)格:：5mg
價(jià)格:：￥660
我知道了
在線客服
產(chǎn)品詳情

Ferrostatin-1 是一種有效的、選擇性的 ferroptosis 抑制劑，抑制 Erastin 誘導(dǎo)的 HT-1080 細(xì)胞鐵死亡 (EC50=60 nM)。Ferrostatin-1 是一種人工合成的抗氧化劑，通過還原機(jī)制來防止膜脂的損傷，從而抑制細(xì)胞死亡。具有抗真菌活性。

生物活性
 Ferrostatin-1, a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity[1][2][3].
IC50 & Target
 EC50: 60 nM (Ferroptosis)[1]
體外研究
(In Vitro)
 Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices[1].
Fer-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability[2].
體內(nèi)研究
(In Vivo)

Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction [2].
Ferrostatin-1 (0.8?mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI)[4].
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (LPS-induced ALI)[4]
Dosage: 0.8?mg/kg
Administration: Tail vein injection
Result: Exerted therapeutic action against LPS-induced ALI.

分子量
 262.35
Formula
 C15H22N2O2
CAS 號
 347174-05-4
運(yùn)輸條件
 Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


溶解性數(shù)據(jù)

In Vitro: 

DMSO : 125 mg/mL (476.46 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.8117 mL 19.0585 mL 38.1170 mL
5 mM 0.7623 mL 3.8117 mL 7.6234 mL
10 mM 0.3812 mL 1.9059 mL 3.8117 mL
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲存時(shí)，請?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲存時(shí)，請?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請根據(jù)您的實(shí)驗(yàn)動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都請先按?nbsp;In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

  • 2.

    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

  • 3.

    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

參考文獻(xiàn)

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072.

[2]. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556.

[3]. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078.

[4]. Liu P, Feng Y, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. Published 2020 Feb 27.

[5]. Melania Guerrero Hue, et al. FP282 FERROPTOSIS-MEDIATED CELL DEATH IS DECREASED BY CURCUMIN IN RENAL DAMAGE ASSOCIATED TO RHABDOMYOLYSIS, Nephrology Dialysis Transplantation, Volume 34, Issue Supplement_1, June 2019, gfz106.FP282.



Ferrostatin-1（鐵抑素-1）

Ferrostatin-1（鐵抑素-1）

分享到微信

×
Ferrostatin-1 是一種有效的、選擇性的 ferroptosis 抑制劑，抑制 Erastin 誘導(dǎo)的 HT-1080 細(xì)胞鐵死亡 (EC50=60 nM)。Ferrostatin-1 是一種人工合成的抗氧化劑，通過還原機(jī)制來防止膜脂的損傷，從而抑制細(xì)胞死亡。具有抗真菌活性。
貨號： HY-100579
品牌：MCE
型號： HY-100579
起訂量：1
規(guī)格:：5mg
價(jià)格:：￥660
15906629305
在線客服
產(chǎn)品詳情

Ferrostatin-1 是一種有效的、選擇性的 ferroptosis 抑制劑，抑制 Erastin 誘導(dǎo)的 HT-1080 細(xì)胞鐵死亡 (EC50=60 nM)。Ferrostatin-1 是一種人工合成的抗氧化劑，通過還原機(jī)制來防止膜脂的損傷，從而抑制細(xì)胞死亡。具有抗真菌活性。

生物活性
 Ferrostatin-1, a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity[1][2][3].
IC50 & Target
 EC50: 60 nM (Ferroptosis)[1]
體外研究
(In Vitro)
 Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices[1].
Fer-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability[2].
體內(nèi)研究
(In Vivo)

Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction [2].
Ferrostatin-1 (0.8?mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI)[4].
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (LPS-induced ALI)[4]
Dosage: 0.8?mg/kg
Administration: Tail vein injection
Result: Exerted therapeutic action against LPS-induced ALI.

分子量
 262.35
Formula
 C15H22N2O2
CAS 號
 347174-05-4
運(yùn)輸條件
 Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


溶解性數(shù)據(jù)

In Vitro: 

DMSO : 125 mg/mL (476.46 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.8117 mL 19.0585 mL 38.1170 mL
5 mM 0.7623 mL 3.8117 mL 7.6234 mL
10 mM 0.3812 mL 1.9059 mL 3.8117 mL
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲存時(shí)，請?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲存時(shí)，請?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請根據(jù)您的實(shí)驗(yàn)動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮Ｒ韵氯芙夥桨付颊埾劝凑?nbsp;In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

  • 2.

    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

  • 3.

    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

參考文獻(xiàn)

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072.

[2]. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556.

[3]. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078.

[4]. Liu P, Feng Y, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. Published 2020 Feb 27.

[5]. Melania Guerrero Hue, et al. FP282 FERROPTOSIS-MEDIATED CELL DEATH IS DECREASED BY CURCUMIN IN RENAL DAMAGE ASSOCIATED TO RHABDOMYOLYSIS, Nephrology Dialysis Transplantation, Volume 34, Issue Supplement_1, June 2019, gfz106.FP282.



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